自然杀伤细胞的强大细胞溶解活性对于弓形虫感染的免疫前抗性既非必要条件也非充分条件。
Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.
作者信息
Johnson L L, Sayles P C
机构信息
Trudeau Institute, Inc., Saranac Lake, N.Y., USA.
出版信息
Nat Immun. 1995 Apr;14(4):209-15.
PMID:8696010
Abstract
That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.
摘要
研究表明，自然杀伤（NK）细胞强大的细胞溶解活性对于抵御急性弓形虫感染既非必要条件也非充分条件。尽管NK活性得到了良好诱导，但感染弓形虫的抗干扰素（IFN）-γ处理小鼠和IFN-γ基因敲除小鼠仍死亡，而缺乏NK细胞溶解活性的感染米色小鼠却存活了下来。
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