Levin R M, Hypolite J A, Haugaard N, Wein A J
Division of Urology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Neurourol Urodyn. 1996;15(1):79-84. doi: 10.1002/(SICI)1520-6777(1996)15:1<79::AID-NAU8>3.0.CO;2-C.
Recent studies indicate that the mucosa of the urinary bladder plays a major role in the maintenance of normal bladder function. Previous studies have demonstrated that rabbit bladder mucosa has higher rates of basal glycolysis and oxidative phosphorylation than that of bladder smooth muscle. The current study compares the response of rabbit bladder mucosa and smooth muscle compartments to anoxia. The results demonstrate that the rate of high energy phosphate degradation of the mucosa is significantly greater than the rate of high energy phosphate degradation of the smooth muscle. The implication is that the mucosa would be significantly more sensitive to ischemia than the smooth muscle of the bladder. This hypothesis may be extremely relevant to conditions such as interstitial cystitis and recurrent urinary bladder infections, in which ischemia has been implicated in their etiology.
最近的研究表明，膀胱黏膜在维持正常膀胱功能中起主要作用。先前的研究已证明，兔膀胱黏膜的基础糖酵解和氧化磷酸化速率高于膀胱平滑肌。当前的研究比较了兔膀胱黏膜和平滑肌部分对缺氧的反应。结果表明，黏膜中高能磷酸降解的速率明显高于平滑肌中高能磷酸降解的速率。这意味着黏膜对缺血的敏感性会明显高于膀胱平滑肌。这一假说可能与间质性膀胱炎和复发性膀胱感染等病症极为相关，在这些病症的病因中缺血已被牵连其中。
