Smotriaeva M A, Krugliakova K E, Shishkina L N, Bliukhterova N V, Goloshchapov A N, Burlakova E B
Radiats Biol Radioecol. 1996 Jan-Feb;36(1):21-9.
The complex study on the low gamma-irradiation on the structural feature of lymphocyte DNA and lipid peroxidation (LPO) regulatory system parameters in mice blood was carried out depending on irradiation intensity. It was found that DNA alkaline elution rate constants, viscosity of the different regions of erythrocyte membranes and LPO products content in mice blood plasma varied nonlinearly depending on dose or dose rate. The proportion of the damage types and the range of the DNA structural changes substantially differ depending on the gamma-irradiation dose and its intensity. It is considered that the proportion of the DNA and membrane damage and repair can change depending on radiation dose and dose rate.
根据辐射强度，对低剂量γ射线辐照小鼠血液中淋巴细胞DNA的结构特征和脂质过氧化（LPO）调节系统参数进行了综合研究。结果发现，小鼠血浆中DNA碱性洗脱速率常数、红细胞膜不同区域的粘度以及LPO产物含量随剂量或剂量率呈非线性变化。DNA损伤类型的比例和DNA结构变化的范围因γ射线辐射剂量及其强度的不同而有很大差异。研究认为，DNA和细胞膜损伤与修复的比例会随辐射剂量和剂量率而改变。
