半胱胺对硝西泮药代动力学和药效学的影响。
Influence of cystamine on pharmacokinetics and pharmacodynamics of nitrazepam.
作者信息
Szczawińska K, Cenajek D
出版信息
Arch Immunol Ther Exp (Warsz). 1977;25(2):157-62.
PMID:869675
Abstract
The influence of cystamine on pharmacokinetics of nitrazepam was studied. Experiments were performed on the third day after the administration of cystamine, since the author's previous investigations showed that the protective action of cystamine in radiation sickness was strongest at this time. CA premedication resulted in more rapid resorption, lower level of nitrazepam in blood, and more rapid elimination of the drug.
摘要
研究了半胱胺对硝西泮药代动力学的影响。实验在给予半胱胺后的第三天进行，因为作者之前的研究表明，此时半胱胺对放射病的保护作用最强。半胱胺预处理导致吸收更快，血液中硝西泮水平更低，药物消除更快。
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