Influence of cystamine on pharmacokinetics and pharmacodynamics of nitrazepam.

The influence of cystamine on pharmacokinetics of nitrazepam was studied. Experiments were performed on the third day after the administration of cystamine, since the author's previous investigations showed that the protective action of cystamine in radiation sickness was strongest at this time. CA premedication resulted in more rapid resorption, lower level of nitrazepam in blood, and more rapid elimination of the drug.