Zheng J, Wang S, Yan D
Zhujiang Hospital, First Military Medical College, Guangzhou.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995 Sep;11(5):343-5.
The factors influencing basic fibroblast growth factor (bFGF) to improve wound healing in severe burn were studied. Rats were subjected to 15% III degrees burn. The results showed that high activity of bFGF was maintained after escharectomy in early period. In treated group 84.0% of rats wound healing was observed on the 40th day, while it was 9.0% in control group. Heparin could enhance activity of bFGF to stimulate formation of granulation tissue, regeneration of capillary, proliferation of fibroblast and DNA synthesis. Control of infection was beneficial to preserve activity of bFGF. The authors believe that the proper time to use bFGF is one week after injury.
研究了影响碱性成纤维细胞生长因子（bFGF）促进严重烧伤创面愈合的因素。将大鼠造成15%Ⅲ度烧伤。结果显示，早期切痂后bFGF保持高活性。治疗组84.0%的大鼠在第40天时创面愈合，而对照组为9.0%。肝素可增强bFGF的活性，以刺激肉芽组织形成、毛细血管再生、成纤维细胞增殖及DNA合成。控制感染有利于维持bFGF的活性。作者认为，使用bFGF的适宜时间为伤后1周。
