Pedeutour F, Lacour J P, Perrin C, Huffermann K, Simon M P, Ayraud N, Turc-Carel C
Laboratoire de Génétique Moléculaire des Cancers Humains, URA CNRS 1462, Université de Nice-Sophia Antipolis, France.
Cancer Genet Cytogenet. 1996 Jul 15;89(2):175-6. doi: 10.1016/0165-4608(96)00089-1.
We have identified a new dermatofibrosarcoma protuberans (DP) case with a t(17;22) (q22;q13) occurring in a child. The translocation was substantiated by the presence of one or two copies of the sole der(22)t(17;22). This rearrangement added to two normal chromosomes 17 and one or two chromosomes 22, resulted in trisomy 22cen-q13 and trisomy (or tetrasomy) 17q22-25. This observation confirms the specificity of the association of DP with the t(17;22) found together with extra copies of the der(22)t(17;22). It also points out a possible prevalence of translocation rather than rings in DP of the childhood disease.
