Chen X, Ye Y, Luo W
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Aug;18(4):221-3, 255.
H2 receptor (H2R) is one of the three histamine receptor subtypes. In order to explore the relationship between H2R and the pathogenesis of bronchial asthma, we investigated the effects of H2R agonist impromidine on guinea-pig isolated tracheal smooth muscle and the effects of dimaprit on the lung function of guinea-pigs provoked by antigen.
(1) Impromidine (10(6) mol/L) relaxed partly the guinea-pig isolated tracheal spirals contricted by histamine challenge. After pretreating the spirals with impromidine, the maximum response to histamine was reduced in a dose-dependent manner and the cumulative dose-response curve to histamine was shifted to right. (2) Dimaprit (3mg/kg) given by intravenous injection protected the lung function from damage caused by antigen. These results suggest that H2R agonist produces relaxation of guinea-pig tracheal smooth muscle and inhibits the release of inflammatory mediators in anaphylactic reaction. We concluded that H2R plays some protective roles in the pathogenesis of bronchial asthma.
H2受体（H2R）是三种组胺受体亚型之一。为了探讨H2R与支气管哮喘发病机制之间的关系，我们研究了H2R激动剂英普咪定对豚鼠离体气管平滑肌的作用以及二甲双胍对抗原激发的豚鼠肺功能的影响。
（1）英普咪定（10⁻⁶mol/L）部分舒张了组胺激发收缩的豚鼠离体气管螺旋条。用英普咪定预处理螺旋条后，对组胺的最大反应呈剂量依赖性降低，组胺的累积剂量-反应曲线右移。（2）静脉注射二甲双胍（3mg/kg）可保护肺功能免受抗原引起的损伤。这些结果表明，H2R激动剂可使豚鼠气管平滑肌舒张，并抑制过敏反应中炎症介质的释放。我们得出结论，H2R在支气管哮喘的发病机制中起一定的保护作用。
