Yang X, Mao B, Qian G
Respiratory Centre, Xinqiao Hospital, Third Military Medical University, Chongqing.
Zhonghua Nei Ke Za Zhi. 1995 Aug;34(8):531-5.
The changes of the structure, content and anion transport function as well as the blood gases and electrolytes inside and outside the erythrocytes were investigated in 3 groups of subjects: type I respiratory failure patients (group 1, n = 40); type II respiratory failure patients (group 2, n = 40) and controls (group 3, n = 37). The results showed that (1) anion transport function impairment of erythrocyte membrane band 3 protein and HCO3-/Cl- exchange restrain may be the reasons that aggravate CO2 retention and respiratory acidosis in cor pulmonale patients with type II respiratory failure. (2) band 3 protein anion transport function impairment in patients of cor pulmonale with type II respiratory failure is reversible. Therefore, it was necessary to supply oxygen to cor pulmonale patients with hypoxemia in time, which may contribute to the recovery of anion transport function.
对三组受试者进行了研究，包括I型呼吸衰竭患者（第1组，n = 40）；II型呼吸衰竭患者（第2组，n = 40）和对照组（第3组，n = 37），观察了红细胞膜结构、内容物、阴离子转运功能以及红细胞内外的血气和电解质变化。结果显示：（1）红细胞膜带3蛋白阴离子转运功能受损及HCO3-/Cl-交换受抑制可能是加重II型呼吸衰竭肺心病患者二氧化碳潴留和呼吸性酸中毒的原因。（2）II型呼吸衰竭肺心病患者带3蛋白阴离子转运功能受损是可逆的。因此，及时给低氧血症的肺心病患者供氧，可能有助于阴离子转运功能的恢复。
