[钙调蛋白拮抗剂对原代培养肺癌细胞化学敏感性的影响]
[Effect of calmodulin antagonist on chemosensitivity of primary cultured lung cancer cells].
作者信息
Xiong W, Shen H
机构信息
Southwestern Hospital, Third Military Medical University, Chongqing.
出版信息
Zhonghua Zhong Liu Za Zhi. 1995 Sep;17(5):347-9.
PMID:8697972
Abstract
The effect of calmodulin antagonist trifluoperazine (TFP) on in vitro drug sensitivity of primary cultured lung cancer cells was studied in 28 cases with MTT assay. TFP was found to enhance significantly the anticancer activities of VCR, ADR and VP16 (P < 0.01 or < 0.05). But TFP could not sensitize tumor cells to DDP. TFP may therefore be useful as an adjunct in chemotherapy of lung cancer.
摘要
采用MTT法，在28例患者中研究了钙调蛋白拮抗剂三氟拉嗪（TFP）对原代培养肺癌细胞体外药物敏感性的影响。结果发现，TFP可显著增强长春新碱（VCR）、阿霉素（ADR）和依托泊苷（VP16）的抗癌活性（P<0.01或<0.05）。但TFP不能使肿瘤细胞对顺铂（DDP）敏感。因此，TFP可能作为肺癌化疗的辅助药物。
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