Zisova L, Sakakushev B
Department of Dermatology, University of Medicine, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 1994;36(4):51-7.
The authors report, for the first time in Bulgarian literature, a case of acne tetrad syndrome in a family. The patients were sisters who were found to have three of the four components of the syndrome: hidradenitis suppurativa, acne conglobata, and cysta pillaris. There was no evidence or anamnestic data for perifolliculitis capitis abscedens et suffodiens. In one of the sisters the syndrome showed a more precipitate clinical picture and was combined with other skin disorders (lichen ruber planus, neurodermitis circumscripta, hirsutismus). The patients had a familial predisposition to acne and pilar cycts. The complete blood analysis, all biochemical parameters, the cytogenetic analysis and hormonal status (testosterone and estrogens) showed no deviation from normal values. The patients did not report any disturbances during their menstrual cycles. The cellular immunity in one of the sisters was depressed. The patients and their children will be closely monitored.
作者首次在保加利亚文献中报道了一个家族中的痤疮四联症病例。患者为姐妹俩，她们被发现患有该综合征四个组成部分中的三个：化脓性汗腺炎、聚合性痤疮和毛囊囊肿。没有深部穿掘性头皮毛囊周围炎的证据或既往史资料。其中一名姐妹的综合征临床表现更为急骤，且合并了其他皮肤疾病（扁平苔藓、局限性神经性皮炎、多毛症）。患者有痤疮和毛囊囊肿的家族易感性。全血细胞分析、所有生化参数、细胞遗传学分析及激素状态（睾酮和雌激素）均显示无异常值偏差。患者未报告月经周期有任何紊乱。其中一名姐妹的细胞免疫功能低下。将对患者及其子女进行密切监测。
