儿茶酚铁载体合成在创伤弧菌毒力中的作用。
Role of catechol siderophore synthesis in Vibrio vulnificus virulence.
作者信息
Litwin C M, Rayback T W, Skinner J
机构信息
Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA.
出版信息
Infect Immun. 1996 Jul;64(7):2834-8. doi: 10.1128/iai.64.7.2834-2838.1996.
Abstract
We isolated a Vibrio vulnificus TnphoA mutant that was unable to produce catechol siderophores or to acquire iron from transferrin. This mutant showed reduced virulence in an infant mouse model. The TnphoA insertion was in an open reading frame designated venB. The venB gene cloned on a plasmid restored catechol production to the mutant. The deduced amino acid sequence of venB is 41% identical to the enzyme isochorismatase of Escherichia coli (EntB), an enzyme involved in the biosynthesis of the catechol siderophore enterobactin.
摘要
我们分离出了一株创伤弧菌TnphoA突变体，该突变体无法产生儿茶酚铁载体，也无法从转铁蛋白中获取铁。在幼鼠模型中，此突变体的毒力降低。TnphoA插入位点位于一个名为venB的开放阅读框中。克隆在质粒上的venB基因可使突变体恢复儿茶酚的产生。venB推导的氨基酸序列与大肠杆菌的异分支酸酶（EntB）有41%的同源性，EntB是一种参与儿茶酚铁载体肠杆菌素生物合成的酶。
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