Morino T, Shimada K, Masuda A, Yamashita N, Nishimoto M, Nishikiori T, Saito S
Research and Development Division, Nippon Kayaku Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1996 Jun;49(6):564-8. doi: 10.7164/antibiotics.49.564.
Structures of novel immunosuppressants, stevastelin A, B and B3(1) were determined by their spectroscopic and chemical studies. Three stevastelins were shown to be cyclic depsipeptides composed of a fatty acid and three amino acid moieties. The sequence of these moieties was determined to be as 3,5-dihydroxy-2,4-dimethylstearylvalylthreonyl (or O-sulfonylthreonyl in stevastelin A)-O-acetylserine. Cyclic structures were shown to be formed by ester linkages between the carboxylic group of the O-acetylserine moiety and the 5-hydroxy group of the fatty acid moiety in stevastelin A and B, and the 3-hydroxy group of the fatty acid moiety in stevastelin B3.
