Shimada K, Morino T, Masuda A, Sato M, Kitagawa M, Saito S
Research and Development Division, Nippon Kayaku Co., Ltd., Tokyo, Japan.
J Antibiot (Tokyo). 1996 Jun;49(6):569-74. doi: 10.7164/antibiotics.49.569.
Stevastelin B, obtained from a culture of a Penicillium sp. NK374186, is a novel depsipeptide containing three amino acids and 3,5-dihydroxy-2,4-dimethylstearic acid. The stereochemistry of the three amino acids was determined by HPLC analysis, and the relative configuration of the 3,5-dihydroxy-2,4-dimethylstearic acid was elucidated by chemical conversion and NMR analysis. The absolute stereochemistry of stevastelin B was determined by synthetic methods.
