乳腺癌组织中的芳香化酶——定位及其与患者生殖状态的关系。
Aromatase in breast cancer tissue--localization and relationship with reproductive status of patients.
作者信息
Berstein L M, Larionov A A, Kyshtoobaeva A Sh, Pozharisski K M, Semiglazov V F, Ivanova O A
机构信息
Laboratory of Endocrinology, N. N. Petroy Research Institute of Oncology, St. Petersburg, Russia.
出版信息
J Cancer Res Clin Oncol. 1996;122(8):495-8. doi: 10.1007/BF01187162.
Abstract
The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in different cell types, but the most intensive specific staining was found in malignant cells and it was stronger (P < 0.01) in postmenopausal patients than in patients of reproductive age.
摘要
局部雌激素在乳腺癌中的具体产生部位仍存在争议。在本研究中，使用多克隆兔抗体通过免疫组织化学方法研究了乳腺癌组织中芳香化酶（雌激素生物合成的关键酶）的定位。在不同细胞类型中均发现了细胞质染色，但在恶性细胞中发现了最强的特异性染色，且在绝经后患者中比育龄患者更强（P<0.01）。
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Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders.芳香化酶及其他类固醇生成酶在人类乳腺疾病中的免疫定位
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