长期插管胎儿和哺乳羔羊体内葡萄糖、果糖和乳酸的代谢

Warnes D M, Seamark R F, Ballard F J

Biochem J. 1977 Mar 15;162(3):617-26. doi: 10.1042/bj1620617.

Chronically cannulated sheep foetuses and suckling lambs were injected with 14C-labelled glucose, fructose or lactate, and sequential blood samples taken under conditions of minimal stress and without anaesthesia. 2. Gluconeogenesis from lactate was not detectable in foetal sheep, but the pathway was active in suckling lambs. 3. Fructose utilization rates were low in foetal sheep, with no measurable conversion into glucose or lactate. 4. The high rates of irreversible loss of both glucose and lactate in the foetus were decreased in suckling lambs. Radioactivity from labelled glucose entered both the lactate and fructose pools in foetal sheep, and entered the lactate pool in suckling lambs. 5. A model is proposed in which carbon flow between glucose, fructose and lactate has been quantified in foetal sheep.

对长期插管的绵羊胎儿和哺乳羔羊注射14C标记的葡萄糖、果糖或乳酸，并在最小应激且无麻醉的条件下采集连续的血样。2. 胎儿绵羊中无法检测到由乳酸生成葡萄糖的糖异生作用，但该途径在哺乳羔羊中是活跃的。3. 胎儿绵羊中果糖利用率较低，没有可测量的果糖转化为葡萄糖或乳酸的情况。4. 胎儿中葡萄糖和乳酸不可逆损失的高比率在哺乳羔羊中降低。标记葡萄糖的放射性进入胎儿绵羊的乳酸和果糖库，并进入哺乳羔羊的乳酸库。5. 提出了一个模型，其中已对胎儿绵羊中葡萄糖、果糖和乳酸之间的碳流进行了量化。

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核心技术专利：CN118964589B侵权必究

Warnes D M, Seamark R F, Ballard F J

Biochem J. 1977 Mar 15;162(3):617-26. doi: 10.1042/bj1620617.

Chronically cannulated sheep foetuses and suckling lambs were injected with 14C-labelled glucose, fructose or lactate, and sequential blood samples taken under conditions of minimal stress and without anaesthesia. 2. Gluconeogenesis from lactate was not detectable in foetal sheep, but the pathway was active in suckling lambs. 3. Fructose utilization rates were low in foetal sheep, with no measurable conversion into glucose or lactate. 4. The high rates of irreversible loss of both glucose and lactate in the foetus were decreased in suckling lambs. Radioactivity from labelled glucose entered both the lactate and fructose pools in foetal sheep, and entered the lactate pool in suckling lambs. 5. A model is proposed in which carbon flow between glucose, fructose and lactate has been quantified in foetal sheep.

对长期插管的绵羊胎儿和哺乳羔羊注射14C标记的葡萄糖、果糖或乳酸，并在最小应激且无麻醉的条件下采集连续的血样。2. 胎儿绵羊中无法检测到由乳酸生成葡萄糖的糖异生作用，但该途径在哺乳羔羊中是活跃的。3. 胎儿绵羊中果糖利用率较低，没有可测量的果糖转化为葡萄糖或乳酸的情况。4. 胎儿中葡萄糖和乳酸不可逆损失的高比率在哺乳羔羊中降低。标记葡萄糖的放射性进入胎儿绵羊的乳酸和果糖库，并进入哺乳羔羊的乳酸库。5. 提出了一个模型，其中已对胎儿绵羊中葡萄糖、果糖和乳酸之间的碳流进行了量化。