Sweet M J, Hume D A
Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia.
J Leukoc Biol. 1996 Jul;60(1):8-26. doi: 10.1002/jlb.60.1.8.
Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell surface to the nucleus. The involvement of protein tyrosine kinases, mitogen-activated protein kinases, protein kinase C, G proteins, protein kinase A, ceramide-activated protein kinase, and microtubules in this process are reviewed. At the nuclear level, rel, C/EBP, Ets, Egr, fos, and jun family members have been implicated in activation of LPS-inducible gene expression.
通过作用于巨噬细胞，细菌脂多糖（LPS）或内毒素可引发对宿主具有保护或损伤作用的反应。本综述通过追踪从细胞表面到细胞核的一系列事件，研究了LPS对巨噬细胞的影响。本文还综述了蛋白酪氨酸激酶、丝裂原活化蛋白激酶、蛋白激酶C、G蛋白、蛋白激酶A、神经酰胺活化蛋白激酶和微管在此过程中的作用。在核水平上，rel、C/EBP、Ets、Egr、fos和jun家族成员参与了LPS诱导基因表达的激活。
