Grimmett W G, Dzendolet I, Whyte I
Queensland Flying Obstetric & Gynaecological Service, Roma, Australia.
J Toxicol Clin Toxicol. 1996;34(4):447-52. doi: 10.3109/15563659609013817.
We report the first case of intravenous self-poisoning with Thiodan (30% endosulfan in xylene).
A 28-year-old woman with a past history of epilepsy presented with refractory grand mal seizures after injecting 1 mL of Thiodan intravenously. She developed liver dysfunction, proximal myopathy secondary to rhabdomyolysis and renal failure.
The seizures were terminated with midazolam and thiopentone. Mechanical ventilation was required for nine days. Renal and liver dysfunction resolved with supportive measures only. Hemodialysis was not required. Pulmonary complications and neurological sequelae were minimal with the patient making a full recovery over three months.
The intravenous adminis-tration of a small dose of endosulfan in xylene caused the rapid onset of severe grand mal seizures. The absence of pulmonary edema in this case suggests aspiration to be the cause of pulmonary toxicity due to oral endosulfan poisoning.
