Uchida Y, Minoshima S, Kuyama J, Matsuno N, Uno K, Kitakata Y, Kitahara H
Department of Radiology, Chiba University School of Medicine.
Kaku Igaku. 1996 May;33(5):485-91.
This study evaluates the usefulness of 111In-labeled leukocyte scintigraphy to localize inflammatory foci that cannot be determined by clinical symptoms and other imaging studies. Patients with persistent fever following abdominal surgery (n = 20), suspected post-traumatic osteomyelitis associated with multiple fractures (n = 5), and fever of unknown origin (n = 22) were recruited. In all patients, the exact location of inflammatory foci could not be determined by clinical symptoms and conventional imaging studies. In patients with post-surgical fever, leukocyte scintigraphy localized responsible foci in 65% of patients and provided clinically useful information for the treatment. In patients with multiple fractures, the location of osteomyelitis was diagnosed confidently in only one case (20%). In patients with fever of unknown origin, responsible foci were detected in 18% of patients. Although in those patients positive leukocyte studies provided clinically useful information, overall usefulness seemed to be limited. Leukocyte scintigraphy is able to detect inflammatory foci in patients with post-surgical fever, but less likely to localize responsible foci for post-traumatic osteomyelitis or fever of unknown origin when patients have been examined carefully by clinical symptoms and conventional imaging studies.
本研究评估了¹¹¹铟标记的白细胞闪烁扫描术在定位无法通过临床症状和其他影像学检查确定的炎症病灶方面的实用性。招募了腹部手术后持续发热的患者（n = 20）、疑似与多处骨折相关的创伤后骨髓炎患者（n = 5）以及不明原因发热患者（n = 22）。在所有患者中，临床症状和传统影像学检查均无法确定炎症病灶的确切位置。在术后发热患者中，白细胞闪烁扫描术在65%的患者中定位了责任病灶，并为治疗提供了临床有用信息。在多处骨折患者中，仅1例（20%）确诊了骨髓炎的位置。在不明原因发热患者中，18%的患者检测到了责任病灶。尽管在这些白细胞检查阳性的患者中提供了临床有用信息，但总体实用性似乎有限。白细胞闪烁扫描术能够检测术后发热患者的炎症病灶，但当患者已通过临床症状和传统影像学检查进行仔细检查时，定位创伤后骨髓炎或不明原因发热的责任病灶的可能性较小。
