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[替加利多分散度对其生物利用度的影响]

[The effect of the dispersity of tegalid on its bioavailability].

作者信息

Lopatina N B, Lebedeva M N, Mikhaĭlitsyn F S, Khalikov S S

出版信息

Med Parazitol (Mosk). 1996 Jan-Mar(1):23-5.

PMID:8700005
Abstract

The impact of the new helminthicide Tegalide, a dibromobenzamide derivative, on its pharmacology was investigated. The agent given as a fine-dispersed form was found to be more intensively absorbed by the body and to be in animals' blood for a longer period of time (MRT fine-dispersed and MVR coarse-dispersed were 88.5 and 50.4 hours, respectively). As the fine-dispersed fraction of Tegalide increased, its bioavailability showed an equivalent increase.

摘要

研究了新型驱虫剂替加利德(一种二溴苯甲酰胺衍生物)对其药理学的影响。发现以细分散形式给药的该药物被机体吸收得更充分,并且在动物血液中的存在时间更长(细分散和粗分散的平均滞留时间分别为88.5小时和50.4小时)。随着替加利德细分散部分的增加,其生物利用度也相应增加。

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