Kemink S A, Smals A G, Kloppenborg P W
Academisch Ziekenhuis, afd. Endocriene Ziekten, Nijmegen.
Ned Tijdschr Geneeskd. 1996 Jun 15;140(24):1277-9.
Out of 21 male patients with osteoporosis who visited an outpatient clinic for endocrine diseases in two years (1994-1995), three had systemic mastocytosis as diagnosed histopathologically. Two of these had characteristic features of urticaria pigmentosa, consisting of multiple brown nodules on the skin of trunk and extremities, and a positive Darier sign. In all of them the excretion of the histamine metabolites methylhistamine and methylimidazoleacetic acid in a 24-hour urine specimen was increased. When osteoporosis is diagnosed in men or premenopausal women, underlying pathology could be considered. Cautious investigation of signs and symptoms of systemic mastocytosis in such patients might prove this disease be less rare than is often assumed.
在两年（1994 - 1995年）间到内分泌疾病门诊就诊的21例男性骨质疏松患者中，经组织病理学诊断有3例患有系统性肥大细胞增多症。其中2例具有色素性荨麻疹的特征性表现，包括躯干和四肢皮肤出现多个褐色结节，以及 Darier 征阳性。所有患者24小时尿液标本中组胺代谢产物甲基组胺和甲基咪唑乙酸的排泄量均增加。当男性或绝经前女性被诊断为骨质疏松时，应考虑潜在的病理情况。对此类患者系统性肥大细胞增多症的体征和症状进行谨慎调查，可能会发现这种疾病并不像通常认为的那样罕见。
