Preux P M, Couratier P, Boutros-Toni F, Salle J Y, Tabaraud F, Bernet-Bernady P, Vallat J M, Dumas M
Department of Neurology, Dupuytren University Hospital, Limoges, France.
Neuroepidemiology. 1996;15(3):153-60. doi: 10.1159/000109902.
Amyotrophic lateral sclerosis is a progressive neurological disease of unknown etiology and fatal outcome. Patient management can be aided by careful assessment of prognostic factors. A prospective study of 158 patients was carried out to examine the prognostic significance of age and clinical form at onset. The overall 5-year survival rate was 14.7%. The higher the age was at first symptoms, the worse the prognosis. The bulbar and common forms had a worse prognosis than the pseudo-polyneuritic forms. After adjustment for age, the clinical form at onset remained a prognostic factor. In a multivariate analysis using the Cox model, these two factors remained independent despite the later onset of the bulbar forms. In view of the discrepancies between the different published studies, the evaluation of the survival of an individual patient is of doubtful value.
肌萎缩侧索硬化症是一种病因不明、预后致命的进行性神经疾病。仔细评估预后因素有助于患者管理。对158例患者进行了一项前瞻性研究，以探讨发病时年龄和临床类型的预后意义。总体5年生存率为14.7%。首次出现症状时年龄越高，预后越差。延髓型和普通型的预后比假多神经炎型更差。在对年龄进行调整后，发病时的临床类型仍然是一个预后因素。在使用Cox模型的多变量分析中，尽管延髓型发病较晚，但这两个因素仍然独立。鉴于不同发表研究之间存在差异，对个体患者生存情况的评估价值存疑。
