Khegaĭ M D, Zaĭchik S E
Patol Fiziol Eksp Ter. 1995 Oct-Dec(4):6-7.
The pathogenesis of angiopathic complications was studied in rabbits with alloxan diabetes treated with insulin. The latter was found to affect lipid peroxidation, while the levels of glycosylated proteins remained increased in the aortic wall and red blood cells. It is concluded that enhanced nonenzymatic protein glycosylation in a patient with diabetes mellitus may be one of the factors predisposing to angiopathic complications in diabetes mellitus, irrespective of insulin therapy.
对用胰岛素治疗的四氧嘧啶糖尿病兔的血管病变并发症的发病机制进行了研究。发现胰岛素会影响脂质过氧化作用，而主动脉壁和红细胞中的糖基化蛋白水平仍升高。得出的结论是，糖尿病患者非酶蛋白糖基化增强可能是糖尿病血管病变并发症的易感因素之一，与胰岛素治疗无关。
