McCabe M S, Norris B
Biol Psychiatry. 1977 Apr;12(2):245-54.
The efficacy of ECT in the treatment of depression is well recognized. In mania its efficacy is less well acknowledged. This report compares ECT, chlorpromazine, and no active treatment in mania. Twenty-eight control patients diagnosed as manic were selected from consecutive admissions to the University of Iowa Psychiatric Hospital in the period 1935-1941 when there was no active treatment given. Twenty-eight patients treated with ECT were selected from the period 1945-1949, and 28 chlorpromazine-treated patients were selected from the period 1958-1964. Symptoms sufficient to fulfill a research diagnosis of mania had to be documented in the record for all patients. Results compare symptomatology, duration of hospital admission, discharge condition, discharge category, social recovery, and follow-up. Both ECT and chlorpromazine were superior to no active treatment for outcome measures considered. Ten chlorpromazine-treated patients did not respond satisfactorily to the chlorpromazine treatment but recovered with ECT treatment.
电休克疗法（ECT）治疗抑郁症的疗效已得到广泛认可。而其治疗躁狂症的疗效则鲜为人知。本报告比较了ECT、氯丙嗪及不进行积极治疗这三种方式对躁狂症的治疗效果。选取了1935年至1941年间爱荷华大学精神病医院连续收治的28例被诊断为躁狂症的对照患者，当时未进行积极治疗。从1945年至1949年间选取了28例接受ECT治疗的患者，从1958年至1964年间选取了28例接受氯丙嗪治疗的患者。所有患者的病历中均须记录足以满足躁狂症研究诊断的症状。对症状学、住院时间、出院情况、出院类别、社会康复及随访结果进行了比较。就所考虑的疗效指标而言，ECT和氯丙嗪均优于不进行积极治疗。10例接受氯丙嗪治疗的患者对氯丙嗪治疗反应不佳，但经ECT治疗后康复。
