Sanson B J, Friederich P W, Simioni P, Zanardi S, Hilsman M V, Girolami A, ten Cate J W, Prins M H
Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands.
Thromb Haemost. 1996 Mar;75(3):387-8.
Hereditary deficiencies of the naturally occurring anticoagulants are well recognized conditions predisposing to recurrent venous thromboembolism. Since thrombotic phenomena have been implied as a cause of abortion and stillbirth, we hypothesized that these deficiencies increase the risk of fetal demise. A group of 129 female subjects who had been pregnant at least once and who had a family member with documented venous thrombosis associated with a deficiency of AT, PC or PS were studied. We first assessed the obstetric history and subsequently determined the deficiency status. In the 60 deficient subjects 42 (22.3%) of the 188 pregnancies resulted in miscarriage or stillbirth as compared to 23 (11.4%) of the 202 pregnancies in the 69 non-deficient subjects. The relative risk of abortion and stillbirth per pregnancy for deficient women as compared to non-deficient women was 2.0 (95% C.I. 1.2-3.3).
遗传性天然抗凝物质缺乏是公认的易导致复发性静脉血栓栓塞的疾病。由于血栓形成现象被认为是流产和死产的一个原因，我们推测这些缺乏会增加胎儿死亡的风险。我们研究了一组129名女性受试者，她们至少怀孕过一次，并且有一名家庭成员被记录有与抗凝血酶（AT）、蛋白C（PC）或蛋白S（PS）缺乏相关的静脉血栓形成。我们首先评估她们的产科病史，随后确定其缺乏状态。在60名缺乏抗凝物质的受试者中，188次妊娠中有42次（22.3%）导致流产或死产，而在69名非缺乏抗凝物质的受试者中，202次妊娠中有23次（11.4%）导致流产或死产。与非缺乏抗凝物质的女性相比，缺乏抗凝物质的女性每次妊娠发生流产和死产的相对风险为2.0（95%可信区间1.2 - 3.3）。
