Draper D E
Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
Trends Biochem Sci. 1996 Apr;21(4):145-9.
RNAs are surprisingly adept at folding into specific shapes capable of ligand recognition and catalysis. Thermodynamic analysis of the unfolding of several different RNAs suggests that there are at least three strategies an RNA might use to achieve a very stable and compactly folded structure: hydrogen bonding between irregular complementary surfaces (as in transfer RNA tertiary structure); monovalent and divalent lons bound to specific sites (as found in a ribosomal RNA fragment) and pseudoknot folds (exemplified by a messenger RNA fragment with extensive non-canonical structure).
RNA 惊人地擅长折叠成能够进行配体识别和催化的特定形状。对几种不同 RNA 解折叠的热力学分析表明，RNA 可能至少有三种策略来实现非常稳定且紧密折叠的结构：不规则互补表面之间的氢键作用（如转运 RNA 的三级结构）；结合到特定位点的单价和二价离子（如在核糖体 RNA 片段中发现的）以及假结折叠（以具有广泛非规范结构的信使 RNA 片段为例）。
