Yurdakök M, Yiğit S, Gürakan B, Dündar S, Kirazli S
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Turk J Pediatr. 1996 Apr-Jun;38(2):195-7.
The serum plasminogen status in 35 preterm infants with or without respiratory distress syndrome (RDS) was determined in the first few hours of life. Blood samples for plasminogen testing (Synthetic chromogenic substrate method; Stachorm PLG. Diagnostica Stago) were obtained from a peripheral vein within six hours after birth. Among 35 infants, 20 infants who were in stable clinical condition served as the control group. Fifteen developed RDS with clinical, laboratory and radiological findings. The mean plasma plasminogen levels were found to be similar in the two groups (p > 0.05 by Mann-Whitney U test). These findings are discussed along with our previous findings showing normal tissue plasminogen activator (tPA) but lower D-dimer and higher plasminogen activator inhibitor (PAI) levels within the first few hours of life in preterm infants who later developed RDS compared to the control group.
在出生后的最初几个小时内，对35例患有或未患有呼吸窘迫综合征（RDS）的早产儿的血清纤溶酶原状态进行了测定。用于纤溶酶原检测的血样（合成发色底物法；Stachorm PLG. Diagnostica Stago）在出生后6小时内从外周静脉采集。在这35例婴儿中，20例临床状况稳定的婴儿作为对照组。15例出现了具有临床、实验室和影像学表现的RDS。发现两组的平均血浆纤溶酶原水平相似（Mann-Whitney U检验，p>0.05）。这些发现与我们之前的发现一起进行了讨论，之前的发现表明，与对照组相比，后来发生RDS的早产儿在出生后的最初几个小时内组织纤溶酶原激活物（tPA）正常，但D-二聚体水平较低，纤溶酶原激活物抑制剂（PAI）水平较高。
