Hansen J, Olsen J H
Ugeskr Laeger. 1996 Jul 15;158(29):4191-4.
Formaldehyde is a widespread animal carcinogen with limited evidence of carcinogenesis in humans. We investigated the occupational risk of cancer (1970-84) among men and women in Denmark. Relative risks (RR) were estimated from standardized proportionate incidence ratios among patients whose longest employment had been held since 1964, at least 10 years before diagnosis, in 265 companies in which exposure to formaldehyde was identified. The only biologically plausible increased risk was for nasal cancer, for which relative risks of 2.3 (95% confidence interval = 1.3-4.0) and 2.4 (0.6-6.0) appeared for men and women, respectively. In the subgroup of blue-collar men with no probable exposure to wood-dust, the major confounder, the relative risk for this cancer was 3.0 (1.4-5.7). It is concluded that occupational exposure to formaldehyde may increase the risk of nasal cancer, but formaldehyde does probably not affect other cancers.
甲醛是一种广泛存在的动物致癌物，对人类致癌的证据有限。我们调查了丹麦男性和女性的职业性癌症风险（1970 - 1984年）。相对风险（RR）是根据1964年以来（诊断前至少10年）在265家已确认存在甲醛暴露的公司中就业时间最长的患者的标准化比例发病率估计得出的。唯一在生物学上看似合理的风险增加是鼻癌，男性和女性的相对风险分别为2.3（95%置信区间 = 1.3 - 4.0）和2.4（0.6 - 6.0）。在没有可能接触木屑（主要混杂因素）的蓝领男性亚组中，这种癌症的相对风险为3.0（1.4 - 5.7）。研究得出结论，职业性接触甲醛可能会增加患鼻癌的风险，但甲醛可能不会影响其他癌症。
