Coutts A J, Dawson S, Binns S, Hart C A, Gaskell C J, Gaskell R M
Department of Veterinary Clinical Science, University of Liverpool, UK.
Vet Microbiol. 1996 Jan;48(1-2):19-27. doi: 10.1016/0378-1135(95)00128-x.
Two pregnant specific-pathogen-free (SPF) cats, from a colony endemically infected with Bordetella bronchiseptica, were housed under barrier conditions in the latter stages of pregnancy in order to study the possible transmission of the organism to their kittens. Both queens had antibody titres to Bordetella bronchiseptica of 1 in 320 at the start of the experiment but did not shed Bordetella bronchiseptica until 9 days and 6 weeks after parturition, respectively. Five of the nine kittens had detectable maternally-derived-antibody to Bordetella bronchiseptica which declined to < or = 1 in 40 by two weeks of age. Kittens were weaned at 12 weeks of age. No Bordetella bronchiseptica was isolated from any of the kittens and none seroconverted over this time. At 15 1/2 weeks of age, half of each litter were housed separately and inoculated intra-nasally with 10(8) colony-forming-units B. bronchiseptica. Mild signs of upper respiratory tract disease were seen and the organism was isolated for 19 weeks following inoculation when the experiment ended. Seroconversion occurred at 4 weeks postinoculation. Oral treatment of two clinically-recovered kittens with doxycycline once a day did not eliminate shedding.
从支气管败血波氏杆菌地方流行感染的猫群中选取两只怀孕的无特定病原体（SPF）猫，在妊娠后期置于屏障环境中，以研究该病原体向其幼崽的可能传播情况。实验开始时，两只母猫针对支气管败血波氏杆菌的抗体效价均为1:320，但分别在分娩后9天和6周才开始排出支气管败血波氏杆菌。9只幼崽中有5只检测到来自母体的针对支气管败血波氏杆菌的抗体，到2周龄时抗体效价降至≤1:40。幼崽在12周龄时断奶。在这段时间内，未从任何一只幼崽中分离出支气管败血波氏杆菌，也没有一只发生血清转化。在15.5周龄时，每窝幼崽中的一半被单独饲养，并经鼻内接种10⁸个支气管败血波氏杆菌菌落形成单位。观察到有轻微的上呼吸道疾病症状，接种后19周实验结束时分离到了该病原体。接种后4周发生了血清转化。对两只临床康复的幼崽每天口服一次强力霉素，未能消除排菌现象。
