Heuson J C, Longeval E, Mattheiem W H, Deboel M C, Sylvester R J, Leclercq G
Cancer. 1977 May;39(5):1971-7. doi: 10.1002/1097-0142(197705)39:5<1971::aid-cncr2820390510>3.0.co;2-8.
The predictive significance of quantitative assessment of estrogen receptors in tumor tissue was analyzed in women with advanced breast carcinoma. Receptor concentration was measured by the 3H-estradiol binding capacity of the cytosol fraction of biopsies taken before initiation of the treatment. The E. O. R. T. C. criteria for the assessment of the patients' response were used. In a total of 34 assessments, 25 biopsies contained receptors; the remaining ones were negative. Objective remission to various endocrine therapies was recorded in only eight of the receptor-positive patients. Responses occurred along the whole scale of receptor concentrations with an apparent crowding in the region of the higher values. Linear logistic regression analysis revealed that among 12 variables of known prognostic value, receptor concentration was the most significant in relation to therapeutic response. Other significant variables were bone involvement and age. Computations yielded formulas that are presented in graph form and provide an estimate of the probability of a given patient to respond to endocrine treatments. On the other hand, the results suggest that all patients are possibly hormone dependent, although to variable degrees. The latter concept has very definite therapeutic implications.
对晚期乳腺癌女性患者肿瘤组织中雌激素受体定量评估的预测意义进行了分析。通过治疗开始前活检的细胞溶质部分的3H-雌二醇结合能力来测量受体浓度。采用欧洲癌症研究与治疗组织（E.O.R.T.C.）评估患者反应的标准。在总共34次评估中，25份活检样本含有受体；其余样本为阴性。仅8名受体阳性患者记录到对各种内分泌治疗的客观缓解。反应出现在受体浓度的整个范围内，在较高值区域明显聚集。线性逻辑回归分析显示，在12个已知预后价值的变量中，受体浓度与治疗反应的关系最为显著。其他显著变量是骨转移和年龄。计算得出以图表形式呈现的公式，可估计给定患者对内分泌治疗反应的概率。另一方面，结果表明所有患者可能都有激素依赖性，尽管程度不同。后一概念具有非常明确的治疗意义。
