Du G H, Qiu Y, Zhang J T
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Yao Xue Xue Bao. 1995;30(10):731-5.
The protective effect of salvianolic acid A (Sal A) on cardiac ischemia-reperfusion induced injury was studied on the isolated rat heart. The results indicate that Sal A can reduce the occurence of ventricular fibrillation, decrease the cellular LDH leaking and reduce the concentration of lipid peroxidation product-MDA significantly in ischemia-reperfused cardiac tissue. The possible machenism in decreasing ischemia-reperfusion injury of Sal A was discussed.
研究了丹酚酸A（Sal A）对离体大鼠心脏缺血再灌注损伤的保护作用。结果表明，Sal A可降低室颤的发生率，减少细胞乳酸脱氢酶泄漏，并显著降低缺血再灌注心脏组织中脂质过氧化产物丙二醛（MDA）的浓度。探讨了Sal A减轻缺血再灌注损伤的可能机制。
