石杉碱甲片在6名志愿者体内的药代动力学。
Pharmacokinetics of tablet huperzine A in six volunteers.
作者信息
Qian B C, Wang M, Zhou Z F, Chen K, Zhou R R, Chen G S
机构信息
Department of Pharmacology, Zhejiang Academy of Medical Sciences, Hangzhou, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):396-8.
AIM
To study pharmacokinetics of tablet huperzine A (Hup-A) in Chinese volunteers to help establishing its drug administration schedule.
METHODS
For 6 volunteers after a single oral dose of 0.99 mg, drug concentrations in plasma were assayed by reverse phase high pressure liquid chromatography (HPLC) at 0.5, 0.75, 1.0, 1.25, 1.5, 2, 4, 6, 8, and 10 h. The pharmacokinetic parameters were calculated with a 3P87 program by computer.
RESULTS
The time course of plasma concentrations conformed to a one-compartment open model with a first order absorption. The pharmacokinetic parameters were as follows: T 1/2ka = 12.6 min, T 1/2ke = 288.5 min, Tmax = 79.6 min, Cmax = 8.4 micrograms L-1, AUC = 4.1 mg L-1 min.
CONCLUSION
Hup-A was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate.
目的
研究石杉碱甲片在中国志愿者体内的药代动力学，以助于制定其给药方案。
方法
6名志愿者单次口服0.99毫克后，于0.5、0.75、1.0、1.25、1.5、2、4、6、8和10小时，采用反相高效液相色谱法（HPLC）测定血浆中的药物浓度。药代动力学参数用计算机3P87程序计算。
结果
血浆浓度的时程符合一级吸收的一室开放模型。药代动力学参数如下：吸收半衰期（T1/2ka）=12.6分钟，消除半衰期（T1/2ke）=288.5分钟，达峰时间（Tmax）=79.6分钟，峰浓度（Cmax）=8.4微克/升，药时曲线下面积（AUC）=4.1毫克/升·分钟。
结论
石杉碱甲吸收迅速，在体内分布广泛，消除速率适中。
Zotero 插件