Grigoriou O, Papadias C, Konidaris S, Antoniou G, Karakitsos P, Giannikos L
Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Gynecol Endocrinol. 1996 Apr;10(2):119-23. doi: 10.3109/09513599609097901.
The objective of this study was to compare the efficacy of flutamide and cyproterone acetate in the treatment of hirsutism. Twenty-two women with idiopathic hirsutism were randomized to receive either flutamide or cyproterone acetate. Each patient underwent a complete gynecological examination as well as an endocrinological profile and hematological, hepatic and renal function analyses. Hirsutism scores were determined using a modified Ferriman-Gallwey scoring system. These tests were then repeated at 3 and 9 months of therapy. Eleven patients received 250 mg of flutamide twice daily and 11 patients received 100 mg of cyproterone acetate on days 5-14 of the menstrual cycle. Ferriman-Gallwey scores were decreased significantly in both groups at the end of 9 months. There was a trend towards a better response with flutamide, that did not achieve significance. Another significant difference was the increased sex hormone-binding globulin in both groups. A statistically significant decrease was also observed for the levels of testosterone on both drugs. No subject withdrew from the study due to a side-effect. The data suggest that both flutamide and cyproterone acetate were similarly effective in treatment of hirsutism, and that the pure antiandrogen flutamide is a safe, well-tolerated and effective alternative in treatment.
本研究的目的是比较氟他胺和醋酸环丙孕酮治疗多毛症的疗效。22名特发性多毛症女性被随机分为两组，分别接受氟他胺或醋酸环丙孕酮治疗。每位患者均接受了全面的妇科检查以及内分泌检查、血液学、肝脏和肾脏功能分析。多毛症评分采用改良的费里曼-盖尔维评分系统进行测定。这些检查在治疗的第3个月和第9个月重复进行。11名患者每天两次服用250毫克氟他胺，11名患者在月经周期的第5至14天服用100毫克醋酸环丙孕酮。9个月末两组的费里曼-盖尔维评分均显著降低。氟他胺组的反应有更好的趋势，但未达到显著差异。另一个显著差异是两组的性激素结合球蛋白均升高。两种药物治疗后睾酮水平均有统计学意义的下降。没有患者因副作用退出研究。数据表明，氟他胺和醋酸环丙孕酮在治疗多毛症方面同样有效，并且纯抗雄激素药物氟他胺是一种安全、耐受性良好且有效的治疗选择。
