Cento R M, Ragusa L, Proto C, Alberti A, Romano C, Boemi G, Colabucci F, Lanzone A
Unit of Obstetrics and Gynecology, Oasi Maria S.S. Institute, Troina, Italy.
Gynecol Endocrinol. 1996 Apr;10(2):133-7. doi: 10.3109/09513599609097904.
We examined the basal body temperature curves and the endocrine pattern of 20 cycles from women with Down syndrome with regular menstrual cycles. Data were compared with those obtained from an age-matched population of healthy women with regular menses. Growth hormone deficiency was excluded for women with Down syndrome by pharmacological tests. Women with Down syndrome showed a significantly higher incidence of anovulation and luteal defects than controls (p < 0.001). Overall, and in ovulatory cycles, estradiol and progesterone plasma levels were greater in controls than in women with Down syndrome. No difference was observed for gonadotropin and androgen circulating levels between the two groups. It is concluded that in women with Down syndrome with regular menses, ovulatory events were less frequent and often characterized by luteal defects. This could be ascribed to an impairment of both follicular and luteal functions. However, reproduction is possible in such patients.
我们研究了月经周期规律的唐氏综合征女性20个周期的基础体温曲线和内分泌模式。将数据与从年龄匹配的月经规律的健康女性群体中获得的数据进行比较。通过药理学测试排除了唐氏综合征女性的生长激素缺乏症。唐氏综合征女性的无排卵和黄体缺陷发生率明显高于对照组（p < 0.001）。总体而言，在排卵周期中，对照组的雌二醇和孕酮血浆水平高于唐氏综合征女性。两组之间的促性腺激素和雄激素循环水平未观察到差异。结论是，月经规律的唐氏综合征女性排卵事件较少，且常以黄体缺陷为特征。这可能归因于卵泡和黄体功能的损害。然而，这类患者仍有可能生育。
