Miyata M, Biro S, Arima S, Hamasaki S, Kaieda H, Nakao S, Kawataki M, Nomoto K, Tanaka H
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Am Heart J. 1996 Aug;132(2 Pt 1):269-73. doi: 10.1016/s0002-8703(96)90421-4.
To determine the relation between the concentration of lipoprotein(a) [Lp(a)] and restenosis after percutaneous transluminal coronary angioplasty (PTCA) in Japan, we studied 80 consecutive patients with single-vessel disease who successfully underwent PTCA. All were evaluated by follow-up angiography a mean of 6.9 months after PTCA and were divided into the restenosis (30 patients) and the non-restenosis (50 patients) groups. The serum Lp(a) concentration of 29 +/- 17 mg/dl in the restenosis group was significantly higher than that of 17 +/- 14 mg/dl in the nonrestenosis group (p < 0.01). Multiple logistic regression analysis for risk factors revealed a significant correlation between restenosis and Lp(a) (p < 0.003). The serum Lp(a) concentration was positively correlated with the coronary artery percent stenosis at the time of follow-up angiography (r = 0.32, p < 0.01). High serum concentration of Lp(a) is therefore a risk factor for restenosis after PTCA in Japan.
为确定日本经皮腔内冠状动脉成形术（PTCA）后脂蛋白(a) [Lp(a)]浓度与再狭窄之间的关系，我们研究了80例连续的单支血管病变患者，这些患者均成功接受了PTCA。所有患者在PTCA后平均6.9个月时接受了随访血管造影，并被分为再狭窄组（30例患者）和无再狭窄组（50例患者）。再狭窄组的血清Lp(a)浓度为29±17mg/dl，显著高于无再狭窄组的17±14mg/dl（p<0.01）。对危险因素进行的多因素logistic回归分析显示，再狭窄与Lp(a)之间存在显著相关性（p<0.003）。血清Lp(a)浓度与随访血管造影时的冠状动脉狭窄百分比呈正相关（r = 0.32，p<0.01）。因此，高血清Lp(a)浓度是日本PTCA后再狭窄的一个危险因素。
