6-O-(2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷对硝基苯酯和O-β-D-吡喃半乳糖基-(1→3)-O-(2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基)-(1→6)-β-D-吡喃半乳糖苷对硝基苯酯的合成
Synthesis of p-nitrophenyl 6-O-(2-acetamido-2-deoxy-beta-d-glucopyranosyl)-beta-D-galactopyranoside and p-nitrophenyl O-beta-D-galactopyranosyl-(1 linked to 3)-O-(2-acetamido-2-dexoy-beta-D-glucopyranosyl)-(1 linked to 6)-beta-D-galactopyranoside.
作者信息
Matta K L, Barlow J J
出版信息
Carbohydr Res. 1977 Feb;53(2):209-16. doi: 10.1016/s0008-6215(00)88088-x.
Condensation of 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-alpha-D-glucopyrano)-[2',1':4,5]-2-oxazoline with p-nitrophenyl 2,3-di-O-acetyl-beta-D-galactopyranoside (4), followed by saponification of the resulting disaccharide derivative, produced p-nitrophenyl 6-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-beta-D-galactopyranoside as a crystalline compound. Reaction of 2-methyl-[4,6-di-O-acetyl-1,2-dideoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-alpha-D-glucopyrano]-[2',1':4,5]-2-oxazoline with 4 in a similar reaction-sequence provided the title trisaccharide compound.
2-甲基-(3,4,6-三-O-乙酰基-1,2-二脱氧-α-D-吡喃葡萄糖基)-[2',1':4,5]-2-恶唑啉与对硝基苯基 2,3-二-O-乙酰基-β-D-吡喃半乳糖苷(4)缩合，随后将所得二糖衍生物皂化，得到对硝基苯基 6-O-(2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖基)-β-D-吡喃半乳糖苷，为结晶化合物。2-甲基-[4,6-二-O-乙酰基-1,2-二脱氧-3-O-(2,3,4,6-四-O-乙酰基-β-D-吡喃半乳糖基)-α-D-吡喃葡萄糖基]-[2',1':4,5]-2-恶唑啉与 4 按照类似的反应顺序反应，得到标题三糖化合物。
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