Khouri I F, Ippoliti C, Gajewski J, Przepiorka D, Champlin R E
University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.
Am J Hematol. 1996 Aug;52(4):313-5. doi: 10.1002/(SICI)1096-8652(199608)52:4<313::AID-AJH12>3.0.CO;2-E.
Cytopenias following bone marrow transplantation may be severe and life-threatening. These have been described post-allogeneic Klumpp, 1991: Bone Marrow Transplant 8:159-171. or post-autologous bone marrow transplants Khouri et al., 1994: J Clin Oncol 12:748-758. as well as with peripheral blood stem cell transplantation Klumpp et al., 1992: Am J Hematol 41:215-217. It can be immune mediated, associated on occasions with graft-versus-host disease (GVHD) Anasetti et al., 1989: Blood 4:1054-1058; however, in most cases, the underlying mechanism is uncertain. The treatment of post-transplant cytopenias is not well established, and they are often refractory to immunosuppressive therapy with steroids. Herein we describe two cases of neutropenia after allogeneic bone marrow transplantation that improved after therapy with high-dose intravenous immunoglobulin.
骨髓移植后的血细胞减少可能很严重并危及生命。这些情况已在异基因骨髓移植后被描述（Klumpp，1991年：《骨髓移植》8：159 - 171），或自体骨髓移植后（Khouri等人，1994年：《临床肿瘤学杂志》12：748 - 758），以及外周血干细胞移植后（Klumpp等人，1992年：《美国血液学杂志》41：215 - 217）。它可能是免疫介导的，有时与移植物抗宿主病（GVHD）相关（Anasetti等人，1989年：《血液》4：1054 - 1058）；然而，在大多数情况下，潜在机制尚不清楚。移植后血细胞减少的治疗方法尚未明确确立，并且它们通常对类固醇免疫抑制治疗无效。在此我们描述两例异基因骨髓移植后中性粒细胞减少症患者，在接受大剂量静脉注射免疫球蛋白治疗后病情有所改善。
