3-氨基-1-(3,4-二氯-α-甲基苄基)-2-吡唑啉-5-酮（Bay g 2821），一种新型强效利尿剂。
3-Amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821), a potent diuretic from a new substance class.
作者信息
Möller E, Horstmann H, Meng K, Loew D
出版信息
Experientia. 1977 Mar 15;33(3):382-3. doi: 10.1007/BF02002840.
PMID:870337
Abstract
Chemistry, salidiuretic activity and mechanism of action of 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazolin-5-one (Bay g 2821), a new diuretic, are described. Owing to the initial rapid onset of activity, the reserve in capacity and the additional long duration of activity, this substance represents a potent diuretic and antihypertensive agent.
摘要
本文描述了一种新型利尿剂3-氨基-1-(3,4-二氯-α-甲基苄基)-2-吡唑啉-5-酮（Bay g 2821）的化学性质、促尿钠排泄活性及作用机制。由于其起效迅速、储备能力强且作用持续时间长，该物质是一种强效利尿剂和抗高血压药物。
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