Carrizosa J, Tanphaichitra D, Levison M E
Infect Immun. 1977 Mar;15(3):871-3. doi: 10.1128/iai.15.3.871-873.1977.
A serum-resistant strain of Bacterioides fragilis that did not produce heparinase was used to study the characteristics of B. fragilis endocarditis in the rabbit experimental model. The infective dose required to produce endocarditis in 50% of rabbits was significantly lower for rabbits with left-sided intracardiac catheters (log10 6.3 colony-forming units +/- 0.6/ml) as compared with right-sided intracardiac catheters (log10 7.7 colony-forming units +/- 0.8/ml). After 3 days of infection, bacterial titers of the tricuspid vegetations were significantly lower than titers of aortic vegetations (P less than 0.01), although at 5 days the titers were similar (P greater than 0.05). The weights of tricuspid vegetations, although similar at 3 days (P less than 0.05). There were no spontaneous deaths during 12 days of infection. In rabbits with the catheter removed before infection, bacterial titers were similar to those titers in rabbits with the catheter continuously in place. This model will permit study of various drug regimens for treatment of this disease.
一株不产生肝素酶的脆弱拟杆菌血清耐药菌株被用于在兔实验模型中研究脆弱拟杆菌性心内膜炎的特征。与右侧心内导管相比，左侧心内导管的兔子产生心内膜炎所需的半数感染剂量（log10 6.3菌落形成单位+/- 0.6/ml）显著更低（右侧为log10 7.7菌落形成单位+/- 0.8/ml）。感染3天后，三尖瓣赘生物的细菌滴度显著低于主动脉赘生物的滴度（P<0.01），尽管在5天时滴度相似（P>0.05）。三尖瓣赘生物的重量在3天时相似（P<0.05）。在12天的感染期内无自然死亡。在感染前移除导管的兔子中，细菌滴度与导管持续留置的兔子中的滴度相似。该模型将允许研究治疗这种疾病的各种药物方案。
