Judd H L, Parker D C, Yen S S
J Clin Endocrinol Metab. 1977 May;44(5):865-9. doi: 10.1210/jcem-44-5-865.
Ten prepubertal boys who ranged in age from 6 11/12 to 14 2/12 years were studied for 2 consecutive nights. The subjects went to sleep at their usual times and sleep patterns were monitered polygraphically. Each night blood samples were drawn every 30 min from 1800 to 0600 h and plasma LH and testosterone (T) levels were measured on each sample. During evening wakefulness the mean LH (range 2.8-5.1 mIU/ml) and T (range 31-116 pg/ml) levels were in the normal prepubertal range for each subject. In the 5 youngest subjects (age 6 11/12 to 10 8/12 years) the mean hormone levels during sleep were significantly higher than the wakeful levels in 2 of 9 and 0 of 9 study nights for LH and T, respectively. In contrast, in the older prepubertal boys (age 13 2/12 to 14 2/12 years) the mean levels during sleep were significantly higher than wakeful values during 8 of 9 and 5 of 9 study nights for the same respective hormones. These data suggest that in young prepubertal subjects the sleep related rises of LH and T are either absent or not discernible in the peripheral blood. The prepubertal pattern of sleep-entrained LH and T release may be seen in prepubertal boys approaching the time of puberty and these hormonal rhythms are antecedent to the physical changes of puberty.
对10名青春期前男孩进行了连续两晚的研究，他们的年龄在6又11/12岁至14又2/12岁之间。受试者按平时时间入睡，通过多导睡眠图监测睡眠模式。每天晚上从18:00至06:00每30分钟采集一次血样，检测每份样本的血浆促黄体生成素（LH）和睾酮（T）水平。在夜间清醒期间，每个受试者的平均LH水平（范围为2.8 - 5.1 mIU/ml）和T水平（范围为31 - 116 pg/ml）处于青春期前的正常范围内。在5名最年幼的受试者（年龄为6又11/12岁至10又8/12岁）中，在9个研究夜晚中的2个夜晚，睡眠期间的平均LH水平显著高于清醒水平，而T水平在9个研究夜晚中均无此现象。相比之下，在年龄较大的青春期前男孩（年龄为13又2/12岁至14又2/12岁）中，对于相同的相应激素，在9个研究夜晚中的8个夜晚，睡眠期间的平均水平显著高于清醒时的值，在9个研究夜晚中的5个夜晚也是如此。这些数据表明，在年幼的青春期前受试者中，外周血中与睡眠相关的LH和T升高不存在或难以察觉。接近青春期的青春期前男孩可能会出现睡眠诱导的LH和T释放的青春期前模式，并且这些激素节律先于青春期的身体变化出现。
