经直肠前列腺穿刺活检后的感染——危险因素及抗生素预防

Infection after transrectal core biopsies of the prostate--risk factors and antibiotic prophylaxis.

作者信息

Aus G, Ahlgren G, Bergdahl S, Hugosson J

机构信息

Department of Urology, Ostra Hospital, Göteborg, Sweden.

出版信息

Br J Urol. 1996 Jun;77(6):851-5. doi: 10.1046/j.1464-410x.1996.01014.x.

DOI:10.1046/j.1464-410x.1996.01014.x

PMID:8705220

Abstract

OBJECTIVE

To compare the infection rate between different durations of antibiotic prophylaxis after transrectal core biopsy and to evaluate the impact of possible risk factors.

PATIENTS AND METHODS

The study comprised 491 patients who underwent transrectal core biopsies of the prostate and who were randomized to receive 400 mg of norfloxacin twice daily for one day or one week.

RESULTS

Patients receiving prophylaxis for one week had a significantly lower rate of infection (4.9%) compared to patients who received only two tablets (11%; P < 0.05). The most pronounced effect was seen in those patients with risk factors (e.g. an indwelling catheter, a former history of urinary tract infection, diabetes or prostatitis) in whom the infection rate was reduced from 17.9% to 3.3% (P < 0.02), and febrile infections from 9.5% to 1.1% (P < 0.02).

CONCLUSIONS

Some factors have a clear impact on the risk of developing an infection after transrectal core biopsy. Prophylaxis for one week with norfloxacin is an effective way to minimize these infections.

摘要

目的

比较经直肠穿刺活检术后不同抗生素预防使用时长的感染率，并评估可能的危险因素的影响。

患者与方法

该研究纳入了491例行前列腺经直肠穿刺活检的患者，这些患者被随机分为两组，分别接受每日两次、每次400mg诺氟沙星，为期1天或1周的治疗。

结果

与仅接受两片药物治疗的患者相比，接受1周预防治疗的患者感染率显著更低（4.9% 对比11%；P < 0.05）。在那些具有危险因素（如留置导尿管、既往有尿路感染史、糖尿病或前列腺炎）的患者中，这种效果最为显著，其感染率从17.9%降至3.3%（P < 0.02），发热性感染从9.5%降至1.1%（P < 0.02）。