Aus G, Hermansson C G, Hugosson J, Pedersen K V
Department of Urology, Ostra Hospital, Gothenburg, Sweden.
Br J Urol. 1993 Apr;71(4):457-9. doi: 10.1111/j.1464-410x.1993.tb15992.x.
Transrectal ultrasound scan (TRUS) of the prostate was performed on 511 patients, 391 of whom also underwent between 1 and 5 transrectal 1.2 mm core biopsies. The infection rate in the whole group was 4.1%; 32% of the patients were given antibiotic prophylaxis with norfloxacin 400 mg twice daily for 1 week and in this group the infection rate was 0.8%. In the remaining patients, who received 400 mg norfloxacin at the time of biopsy and another 400 mg the same evening, the infection rate was 5.6%. The only risk factor identified for post-biopsy infection was steroid medication. Only minor discomfort (or none at all) was reported by 95% of patients during the examination procedure. If TRUS was combined with core biopsy 92% reported either minor or no discomfort. Of 78 patients who experienced both finger-guided fine needle aspiration biopsy and TRUS-guided core biopsy 82% preferred the latter procedure. TRUS and core biopsy proved acceptable to most patients. Antibiotic treatment with 2 tablets of norfloxacin failed to prevent infection.
对511例患者进行了前列腺经直肠超声扫描（TRUS），其中391例还接受了1至5次经直肠1.2毫米穿刺活检。整个组的感染率为4.1%；32%的患者接受了诺氟沙星400毫克每日两次、共1周的抗生素预防，该组的感染率为0.8%。在其余患者中，即在活检时接受400毫克诺氟沙星且当晚再服用400毫克的患者中，感染率为5.6%。确定的活检后感染的唯一风险因素是类固醇药物治疗。95%的患者在检查过程中仅报告有轻微不适（或根本没有不适）。如果TRUS与穿刺活检相结合，92%的患者报告有轻微不适或无不适。在78例既接受了手指引导细针穿刺活检又接受了TRUS引导穿刺活检的患者中，82%的患者更喜欢后一种操作。TRUS和穿刺活检对大多数患者来说是可以接受的。服用两片诺氟沙星进行抗生素治疗未能预防感染。
