非溃疡性消化不良患者C14尿素呼气试验值与固相胃排空时间的关系。

Relationship between C14 urea breath test values and solid-phase gastric emptying time in non-ulcer dyspepsia patients.

作者信息

Wang Y J, Chen G H, Wu K L, Lay C S, Chang C S, Poon S K, Hung C K, Kao C H

机构信息

Department of Internal Medicine, Army General Hospital, Taichung, Taiwan, R.O.C.

出版信息

Zhonghua Yi Xue Za Zhi (Taipei). 1996 Apr;57(4):260-5.

PMID:8705877

Abstract

BACKGROUND

Non-ulcer dyspepsia (NUD) is a poorly understood syndrome often found with endoscopic evidence of gastritis; Helicobacter pylori (Hp) is a common and important cause of gastritis. In the recent literature, gastric hypomotility is thought to be a cause of NUD. Thus, this investigation studied the relationship between Hp and delayed gastric emptying in NUD patients.

METHODS

Using a radionuclide-labelled solid meal to calculate gastric emptying time (GET) of 78 NUD patients. The carbon-14 urea breath test (C14 UBT) was used to quantitate Hp infection.

RESULTS

The prevalence of Hp infection in patients with NUD reached 59%. There was a strong association of Hp infection with advanced age (p = 0.0091). There was no significant difference between solid-phase GET and C14 UBT values among three different age groups (young, middle, old) of NUD patients. There was no difference among sex, age, body weight and solid-phase GET between Hp-positive and Hp-negative NUD patients. However the solid-phase GET was significantly prolonged in patients with NUD, compared with the controls.

CONCLUSIONS

Solid-phase GET is not correlated with the C14 UBT values, and Hp gastric colonization does not account for dyspeptic syndrome in NUD patients.

摘要

背景

非溃疡性消化不良（NUD）是一种了解甚少的综合征，常伴有内镜下胃炎的证据；幽门螺杆菌（Hp）是胃炎常见且重要的病因。在最近的文献中，胃动力不足被认为是NUD的一个病因。因此，本研究探讨了NUD患者中Hp与胃排空延迟之间的关系。

方法

采用放射性核素标记的固体餐计算78例NUD患者的胃排空时间（GET）。采用碳-14尿素呼气试验（C14 UBT）定量检测Hp感染情况。

结果

NUD患者中Hp感染率达59%。Hp感染与高龄密切相关（p = 0.0091）。在NUD患者的三个不同年龄组（青年、中年、老年）中，固相GET与C14 UBT值之间无显著差异。Hp阳性和Hp阴性的NUD患者在性别、年龄、体重和固相GET方面无差异。然而，与对照组相比，NUD患者的固相GET显著延长。