Miyamoto T, Mihara M
Department of Dermatology, Tsuyama Central Hospital, Japan.
J Dermatol. 1996 Jun;23(6):405-7. doi: 10.1111/j.1346-8138.1996.tb04042.x.
We report an 85-year-old woman with subcutaneous granuloma annulare. Three nodules developed on her scalp and sacral regions and gradually increased with tenderness. Histologically, a biopsy specimen of the nodule was interpreted as subcutaneous granuloma annulare because palisading granuloma was present in the dermis and subcutaneous fatty tissue. Laboratory tests, including RA, showed no remarkable changes except for hyperglycemia and glycosuria. These nodules spontaneously regressed without medication. One year later, she noted swelling of some lymph nodules in the left axillary region. These were diagnosed as Hodgkin's disease (mixed cellularity type). She was treated with chemotherapy, but died after two months. Subcutaneous granuloma annulare which occurs suddenly in the elderly may be a dermadrome of malignant blood disease.
我们报告一例85岁患有皮下环状肉芽肿的女性。她的头皮和骶部出现了三个结节，并逐渐增大且伴有压痛。组织学上，结节的活检标本被诊断为皮下环状肉芽肿，因为真皮和皮下脂肪组织中存在栅栏状肉芽肿。包括类风湿关节炎（RA）在内的实验室检查除血糖升高和糖尿外无明显变化。这些结节未经药物治疗自行消退。一年后，她注意到左腋窝区域一些淋巴结肿大。这些被诊断为霍奇金病（混合细胞型）。她接受了化疗，但两个月后死亡。老年人突然出现的皮下环状肉芽肿可能是恶性血液病的皮肤表现。
