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相似文献

1
Current status of vitamin D metabolism.维生素D代谢的现状
Proc R Soc Med. 1977 Feb;70(2):89-91. doi: 10.1177/003591577707000209.
2
[Topical clinical problems of vitamin D research (author's transl)].维生素D研究的局部临床问题(作者译)
MMW Munch Med Wochenschr. 1974 Sep 13;116(37):1565-8.
3
The vitamin D endocrine system, calcium metabolism, and osteoporosis.维生素D内分泌系统、钙代谢与骨质疏松症。
Spec Top Endocrinol Metab. 1983;5:83-148.
4
[The role of vitamin D metabolites in the pathology of phosphorus-calcium metabolism].[维生素D代谢产物在磷钙代谢病理学中的作用]
Patol Fiziol Eksp Ter. 1987 Sep-Oct(5):86-91.
5
Vitamin D replacement for cirrhosis-related bone disease.维生素D补充治疗肝硬化相关骨病
Nat Clin Pract Gastroenterol Hepatol. 2006 Dec;3(12):689-99. doi: 10.1038/ncpgasthep0637.
6
Vitamin D deficiency: a culprit in metabolic bone disease.维生素D缺乏:代谢性骨病的一个罪魁祸首。
Prog Food Nutr Sci. 1993 Oct-Dec;17(4):377-99.
7
[Vitamin D. Regulation of vitamin D metabolism and therapy with D metabolites].[维生素D。维生素D代谢的调节及D代谢产物的治疗]
Med Monatsschr Pharm. 1983 Sep;6(9):263-9.
8
[Variability of vitamin D metabolism. Practical aspects].
Arch Fr Pediatr. 1977 Jun-Jul;34(6):565-73.
9
The vitamin D endocrine system.
Adv Intern Med. 1982;27:45-71.
10
[Vitamin D--a panacea in nephrology and beyond].[维生素D——肾脏病及其他领域的万灵药]
Pol Merkur Lekarski. 2009 Nov;27(161):437-41.

本文引用的文献

1
Actinomycin D Inhibition of Vitamin D Action.放线菌素 D 抑制维生素 D 作用。
Science. 1965 Jul 9;149(3680):182-4. doi: 10.1126/science.149.3680.182.
2
Biologically active metabolite of vitamin D3 from bone, liver, and blood serum.来自骨骼、肝脏和血清的维生素D3的生物活性代谢物。
J Lipid Res. 1966 Nov;7(6):739-44.
3
Filter assay for 1alpha, 25-dihydroxyvitamin D3. Utilization of the hormone's target tissue chromatin receptor.1α,25-二羟基维生素D3的滤膜分析。该激素靶组织染色质受体的应用。
Biochemistry. 1974 Sep 24;13(20):4091-7. doi: 10.1021/bi00717a005.
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Action of 1,25-dihydroxycholecalciferol, a potent, kidney-produced metabolite of vitamin D3, in uremic man.
N Engl J Med. 1972 Nov 2;287(18):891-5. doi: 10.1056/NEJM197211022871801.
5
Competitive protein-binding radioassay for 25-hydroxycholecalciferol.25-羟基胆钙化醇的竞争性蛋白结合放射分析
J Clin Endocrinol Metab. 1971 Dec;33(6):992-5. doi: 10.1210/jcem-33-6-992.
6
Unique biosynthesis by kidney of a biological active vitamin D metabolite.肾脏对生物活性维生素D代谢物的独特生物合成。
Nature. 1970 Nov 21;228(5273):764-6. doi: 10.1038/228764a0.
7
25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3.
Biochemistry. 1968 Oct;7(10):3317-22. doi: 10.1021/bi00850a001.
8
25-Hydroxycholecalciferol-1-hydroxylase: a specific requirement for NADPH and a hemoprotein component in chick kidney mitochondria.25-羟胆钙化醇-1-羟化酶:鸡肾线粒体中对烟酰胺腺嘌呤二核苷酸磷酸(NADPH)和一种血红蛋白成分的特殊需求。
Arch Biochem Biophys. 1974 Jan;160(1):63-72. doi: 10.1016/s0003-9861(74)80009-3.
9
The regulation of rat liver calciferol-25-hydroxylase.大鼠肝脏维生素D3-25-羟化酶的调节
J Biol Chem. 1973 May 10;248(9):2969-73.
10
Seasonal variations in serum 25-hydroxycholecalciferol in healthy people.健康人群血清25-羟基胆钙化醇的季节性变化
Lancet. 1974 Mar 30;1(7857):536-8. doi: 10.1016/s0140-6736(74)92717-2.

维生素D代谢的现状

Current status of vitamin D metabolism.

作者信息

Fairney A

出版信息

Proc R Soc Med. 1977 Feb;70(2):89-91. doi: 10.1177/003591577707000209.

DOI:10.1177/003591577707000209
PMID:870898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1542933/
Abstract

In summary one can record that the biochemist has discovered a beautiful metabolic pathway for vitamin D which is probably as yet incomplete. Subsequently the medicinal chemist has provided numerous synthetic analogues. However, delays in the diagnosis and treatment of vitamin D disorders, due to lack of specific assays and inadequate supplies of therapeutic metabolites, still unfortunately exist. It is hoped that these problems will be rectified as soon as more plentiful supplies of the appropriate metabolites are available.

摘要

综上所述,可以记录的是,生物化学家已经发现了一条关于维生素D的美妙代谢途径,而这条途径可能尚未完整。随后,药物化学家提供了众多合成类似物。然而,由于缺乏特异性检测方法以及治疗性代谢物供应不足,维生素D紊乱的诊断和治疗仍存在延误,这实在令人遗憾。希望一旦有更充足的合适代谢物供应,这些问题将尽快得到解决。