不同程度禁水后的苯巴比妥饮水曲线

Phenobarbital drinking curves after varied water deprivation.

作者信息

Schmidt H, Butzer T

出版信息

Pharmacol Biochem Behav. 1977 Feb;6(2):243-4. doi: 10.1016/0091-3057(77)90082-x.

Abstract

The phenobarbital dose-drinking response curves were obtained for 11 1/2 and 23 1/2 hr of water deprivation in rats. The results indicated that the same quadratic curve was found in both cases displaced as a function of degree of deprivation. These results are explicable by regarding phenobarbital as an adequate stimulus for drinking or by disinhibiting drinking if level of inhibition is not directly concerned with regulation of water ingestion per se. The response to phenobarbital upon the days following injection is similar for both degrees of deprivation investigated.

摘要

在大鼠11.5小时和23.5小时禁水的情况下，获得了苯巴比妥剂量-饮水反应曲线。结果表明，在这两种情况下均发现了相同的二次曲线，其位移是禁水程度的函数。如果将苯巴比妥视为饮水的充分刺激因素，或者如果抑制水平与水摄入本身的调节没有直接关系，通过解除抑制来饮水，那么这些结果是可以解释的。在所研究的两种禁水程度下，注射后几天对苯巴比妥的反应是相似的。