Tsai S C, Kao C H, Lee J K, Wang S J
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1996 Feb;12(2):88-92.
This study evaluated the relationships between the alveolar integrity and the pulmonary function in 33 male subjects, including 18 COPD patients, 10 normal volunteers and 5 NIDDM patients. Alveolar integrity was evaluated by dynamic Tc-99m DTPA/HMPAO radioaerosol lung scintigraphies. The speed of radioaerosol clearance is represented as a slope from the lungs to the blood stream. Comprehensive pulmonary function tests included forced expiratory volume, flow-volume loop, and diffusion capacity of a single breath CO method. The results showed the following: that (1) there are no correlations between the slopes and the parameters of pulmonary function tests, and (2) that the clearance of DTPA aerosols is faster than the clearance of HMPAO, and that these differences are significant. In conclusion, the radionuclide alveolar integrity study should be considered as a new method for evaluating lung function, and should be differentiated from traditional pulmonary function tests, and, secondly, lipophilic HMPAO aerosols are slower to clear than those of hydrophilic DTPA, which suggests at least two different clearance mechanisms for radioaerosols.
本研究评估了33名男性受试者的肺泡完整性与肺功能之间的关系，其中包括18名慢性阻塞性肺疾病（COPD）患者、10名正常志愿者和5名非胰岛素依赖型糖尿病（NIDDM）患者。通过动态锝-99m二乙三胺五醋酸（DTPA）/六甲基丙烯胺肟（HMPAO）放射性气溶胶肺闪烁显像评估肺泡完整性。放射性气溶胶清除速度以从肺到血流的斜率表示。全面的肺功能测试包括用力呼气量、流量-容积环和单次呼吸一氧化碳弥散量测定法。结果显示如下：（1）斜率与肺功能测试参数之间无相关性；（2）DTPA气溶胶的清除速度快于HMPAO，且这些差异具有显著性。总之，放射性核素肺泡完整性研究应被视为评估肺功能的一种新方法，且应与传统肺功能测试区分开来，其次，亲脂性HMPAO气溶胶的清除速度比亲水性DTPA气溶胶慢，这表明放射性气溶胶至少有两种不同的清除机制。
