尿液中Tamm-Horsfall糖蛋白水平升高提示间质性膀胱炎的全身性病因。
Increased urinary levels of Tamm-Horsfall glycoprotein suggest a systemic etiology of interstitial cystitis.
作者信息
Bade J J, Marrink J, Karrenbeld A, van der Weele L, Mensink H J
机构信息
Department of Urology, University Hospital Groningen, The Netherlands.
出版信息
J Urol. 1996 Sep;156(3):943-6.
PURPOSE
We investigated the role of Tamm-Horsfall protein in interstitial cystitis.
MATERIALS AND METHODS
Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.
RESULTS
Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases.
CONCLUSIONS
The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.
目的
我们研究了Tamm-Horsfall蛋白在间质性膀胱炎中的作用。
材料与方法
分析间质性膀胱炎患者和对照组的尿Tamm-Horsfall蛋白排泄情况，并对膀胱活检标本进行Tamm-Horsfall蛋白免疫组织化学染色。
结果
28例间质性膀胱炎女性患者的尿Tamm-Horsfall蛋白水平在统计学上显著高于25例女性对照组。10例间质性膀胱炎病例的膀胱组织中未显示Tamm-Horsfall蛋白阳性染色。
结论
结果支持间质性膀胱炎可能有全身性病因这一观点。此外，该检测方法可能在间质性膀胱炎的诊断中具有临床价值。
Zotero 插件