Bade J J, Marrink J, Karrenbeld A, van der Weele L, Mensink H J
Department of Urology, University Hospital Groningen, The Netherlands.
J Urol. 1996 Sep;156(3):943-6.
We investigated the role of Tamm-Horsfall protein in interstitial cystitis.
Urinary Tamm-Horsfall protein excretion was analyzed in interstitial cystitis patients and controls, and bladder biopsy specimens were stained immunohistochemically for Tamm-Horsfall protein.
Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. No positive staining for Tamm-Horsfall protein was demonstrated in the bladder tissue from 10 interstitial cystitis cases.
The results support the notion that interstitial cystitis may have a systemic etiology. In addition, this assay might have clinical value in the diagnosis of interstitial cystitis.
我们研究了Tamm-Horsfall蛋白在间质性膀胱炎中的作用。
分析间质性膀胱炎患者和对照组的尿Tamm-Horsfall蛋白排泄情况，并对膀胱活检标本进行Tamm-Horsfall蛋白免疫组织化学染色。
28例间质性膀胱炎女性患者的尿Tamm-Horsfall蛋白水平在统计学上显著高于25例女性对照组。10例间质性膀胱炎病例的膀胱组织中未显示Tamm-Horsfall蛋白阳性染色。
结果支持间质性膀胱炎可能有全身性病因这一观点。此外，该检测方法可能在间质性膀胱炎的诊断中具有临床价值。
