一氧化氮合酶抑制剂L-NAME脊髓内注射对大鼠慢性鞘内注射吗啡诱导的脊髓耐受和依赖性的影响。
Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat.
作者信息
Dunbar S, Yaksh T L
机构信息
Department of Anesthesiology 0818, University of California, San Diego, La Jolla 92093, USA.
出版信息
Neurosci Lett. 1996 Mar 22;207(1):33-6. doi: 10.1016/0304-3940(96)12481-2.
Systemic L-NG-nitroarginine methyl ester or L-NAME (LN), a nitric oxide synthase inhibitor, has been reported to attenuate systemic opioid tolerance and withdrawal. Intrathecal co-administration of LN (100 and 500 nmol/microliter per h) with spinal morphine produced only a small diminishing attenuation of tolerance and attenuated only one of seven signs of withdrawal. These results show that LN has little effect on morphine tolerance and withdrawal at spinal sites.
系统给予L-NG-硝基精氨酸甲酯或L-NAME（LN），一种一氧化氮合酶抑制剂，据报道可减轻全身阿片类药物耐受性和戒断反应。鞘内联合给予LN（每小时100和500纳摩尔/微升）与脊髓吗啡，仅产生对耐受性的轻微减弱，且仅减轻了七种戒断症状之一。这些结果表明，LN对脊髓部位的吗啡耐受性和戒断反应影响很小。
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