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接受Björk-Shiley和Lillehei-Kaster主动脉瓣盘式人工瓣膜置换术患者的动脉血栓栓塞并发症

Arterial thromboembolic complications in patients with Björk-Shiley and Lillehei-Kaster aortic disc valve prostheses.

作者信息

Dale J

出版信息

Am Heart J. 1977 Jun;93(6):715-22. doi: 10.1016/s0002-8703(77)80066-5.

Abstract

Arterial thromboembolic complications were studied in 196 patients who had either a single Björk-Shiley or Lillehei-Kaster aortic disc valve implanted. Eight patients suffered from such complications in the course of the first postoperative month and three of them died, two from myocardial infarction and one from cerebral embolism. Nineteen late thromboembolic complications developed in 18 of the 164 patients who survived the postoperative period, the incidence bein 5.9 episodes per 100 patients per year. The two valve types wer found to be equallly thrombogenic, and the rate was not lower than that in patients with Starr-Edwards aortic ball valves of series 2,300 previously studied. Particularly serious was valve malfunction caused by thrombi that limited the movement of the discs. Early recognition of this condition is essential, because the only effective therapy is removal of the thrombus. Three patients with a Björk-Shiley and one with a Lillehei-Kaster valve suffered this complecation and two died, while cerebral embolism caused a third late death. Two of the three patients who had not received anticoagulants developed thromboembolic complications, while most episodes occurred in spite of well-maintained anti-coagulant treatment. It is concluded that arterial thromboembolic complications remain a considerable problem also after aortic disc valve implantation, and that thrombotic valve malfunction is particularly serious and requires special attention.

摘要

对196例植入了单个Björk-Shiley或Lillehei-Kaster主动脉瓣的患者的动脉血栓栓塞并发症进行了研究。8例患者在术后第一个月内出现此类并发症,其中3例死亡,2例死于心肌梗死,1例死于脑栓塞。在术后存活的164例患者中的18例出现了19例晚期血栓栓塞并发症,发生率为每100例患者每年5.9次发作。发现这两种瓣膜类型的血栓形成倾向相同,且该发生率不低于之前研究的2300例Starr-Edwards主动脉球瓣患者。特别严重的是血栓导致瓣膜功能障碍,限制了瓣叶的活动。早期识别这种情况至关重要,因为唯一有效的治疗方法是清除血栓。3例植入Björk-Shiley瓣膜和1例植入Lillehei-Kaster瓣膜的患者出现了这种并发症,2例死亡,而脑栓塞导致了第3例晚期死亡。3例未接受抗凝治疗的患者中有2例出现了血栓栓塞并发症,而尽管抗凝治疗维持良好,仍有大多数发作发生。得出的结论是,动脉血栓栓塞并发症在主动脉瓣植入后仍然是一个相当大的问题,并且血栓性瓣膜功能障碍尤为严重,需要特别关注。

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