Hansson M, Asea A, Hermodsson S, Hellstrand K
Department of Virology, University of Göteborg, Sweden.
Scand J Immunol. 1996 Aug;44(2):193-6. doi: 10.1046/j.1365-3083.1996.d01-291.x.
Human natural killer (NK) cells (with CD3-/56+ phenotype) acquired features characteristic of apoptosis after incubation with autologous monocytes, as revealed by apoptotic nuclear morphology and degradation of DNA into oligonucleosomal fragments. The monocyte-induced apoptosis in NK-cells was prevented by the biogenic amine histamine at concentrations exceeding 0.1 microM. The protective effect of histamine was blocked by the H2-receptor (H2R) antagonist ranitidine but not by AH202399 A, a chemical control to ranitidine devoid of H2R affinity. It is concluded that histaminergic mechanisms may serve to protect NK cells from damage inflicted by products of the oxidative metabolism of monocytes.
人自然杀伤（NK）细胞（具有CD3 - /56 +表型）在与自体单核细胞孵育后呈现出凋亡特征，这通过凋亡核形态以及DNA降解为寡核小体片段得以揭示。浓度超过0.1微摩尔的生物胺组胺可阻止单核细胞诱导的NK细胞凋亡。组胺的保护作用可被H2受体（H2R）拮抗剂雷尼替丁阻断，但不被与雷尼替丁化学结构类似但无H2R亲和力的AH202399 A阻断。结论是组胺能机制可能有助于保护NK细胞免受单核细胞氧化代谢产物造成的损伤。
